Organotin toxicity
WitrynaMechanism of Toxicity. Organotin compounds exert a number of cellular, biochemical, and molecular effects, and toxicity is primarily influenced by bioavailability of the toxicant, route of exposure, and the level and time course of exposure. Both di- and trialkyltin compounds are potent inhibitors of mitochondrial oxidative phosphorylation. WitrynaORGANOTIN (Methyl and Butyl) TOXICITY Occurrence Tin (Sn) is a silver metal (atomic number 50) that occurs in the earth's crust mainly as cassiterite or tinstone (SnO2) …
Organotin toxicity
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Organotin chemistry is the scientific study of the synthesis and properties of organotin compounds or stannanes, which are organometallic compounds containing tin carbon bonds. The first organotin compound was diethyltin diiodide ((CH3CH2)2SnI2), discovered by Edward Frankland in 1849. … Zobacz więcej Organotin compounds are generally classified according to their oxidation states. Tin(IV) compounds are much more common and more useful. Organic derivatives of tin(IV) The … Zobacz więcej Organotin compounds can be synthesised by numerous methods. Classic is the reaction of a Grignard reagent with tin halides for example tin tetrachloride. An example is … Zobacz więcej An organotin compound is commercially applied as stabilizers in polyvinyl chloride. In this capacity, they suppress degradation by removing allylic chloride groups and by absorbing hydrogen chloride. This application consumes about 20,000 tons of tin each … Zobacz więcej • Organostannane addition • Tributyltin azide • Carbastannatranes Zobacz więcej Important reactions, discussed above, usually focus on organotin halides and pseudohalides with nucleophiles. In the area of organic synthesis, the Stille reaction is considered important. It entails coupling reaction with sp -hybridized organic halides (e.g. Zobacz więcej The toxicities of tributyltin and triphenyltin derivatives compounds are comparable to that of hydrogen cyanide. Furthermore, tri-n-alkyltins are Zobacz więcej • National Pollutant Inventory Fact Sheet for organotins • Industry information site • Organotin chemistry in synthesis Zobacz więcej WitrynaToxicity of organotin compounds: Shared and unshared biochemical targets and mechanisms in animal cells. Toxicology in Vitro 2013, 27, 978-990. DOI: 10.1016/j.tiv.2012.12.002. Masaaki Suzuki, Misato Takashima-Hirano, Hiroko Koyama, Takafumi Yamaoka, Kengo Sumi, Hiroko Nagata, Hiroyoshi Hidaka, Hisashi Doi. …
Witryna11 kwi 2024 · The discovery of cisplatin has influenced scientists to study the anticancer properties of other metal complexes. Organotin(IV) dithiocarbamate compounds are gaining attention as anticancer agents due to their potent cytotoxic properties on cancer cells. In this study, a series of organotin compounds were assessed for their toxic … WitrynaSome organotins are classified as persistent, bioaccumulative, toxic, very persistent and very bioaccumulative. Certain organotins can be toxic to aquatic life. Some organotins may act as immunotoxins. Certain organotin compounds are endocrine disruptors and pose toxicity to reproduction.1
WitrynaThe toxicology and biomedical aspects and applications of organotin compounds are discussed. Factors affecting toxicity are considered first and then the mechanisms of toxicity are described and asse... WitrynaOrganotin compounds are harmful and toxic to the aquatic organisms at low concentration. Certain tin compounds e.g. DBT, TBT, may cause skin irritation and …
Witryna5 paź 2005 · Organotin compounds are important environmental pollutants, in part because of their toxicity. Braman et al. (1979) reported that methyltin compounds, including TMT, were detected at concentrations between 0.5 …
WitrynaOrganotin compounds have a broad range of applications. While dialkyltin compounds are used primarily as stabilizers for plastics, trisubstituted organotins are mainly used … jock clothesWitryna22 maj 2024 · Organotin compounds (OTs) are synthetic persistent organometallic xenobiotics widely used in several commercial applications. They exert well-described … integral of absolute value sinxWitrynaOrganotin compounds are ubiquitous contaminants in the environment. The high biological activity of some compounds toward aquatic organisms lead to deleterious impacts in aquatic ecosystems. Here, the aquatic ecotoxicology of organotins is reviewed based on a multidisciplinary approach involving environmental chemical, toxicological, … integral of abs value xWitryna16 mar 2010 · However, such organotin compounds are very toxic. They have mutagenic as well as carcinogenic effects. They are harmful not only for humans but also for … jock charactersWitrynaTaylor & Francis Online: Peer-reviewed Journals integral of a graph in excelWitrynaToxicity: Trimethyltin chloride and other organotin compounds are highly toxic by ingestion, inhalation, or skin contact. Trimethyltin chloride can cause irritation and burns of the skin and eyes. Organotin compounds can affect the central nervous system. The degree of toxicity is greatest for compounds with three or four alkyl groups attached ... integral of absolute value of cos xWitrynaOrganotins such as tributyltin are suspected of having multiple toxic effects in mammals, in addition to their endocrine-disrupting function. Endogenous organotin concentrations in human blood range from a few to a few hundred nM. In this review, we summarize recent findings on the mechanisms of tox … integral of an exponent