WebPathway modules. Glycan metabolism. Glycan biosynthesis. M00070 Glycosphingolipid biosynthesis, lacto-series. M00071 Glycosphingolipid biosynthesis, neolacto-series. WebThis work shows that the liver X receptor (LXR) regulates glycosphingolipid biosynthesis expression in primary human T cells, thereby influencing T cell plasma membrane lipid composition, subsequent immune synapse formation, and T cell receptor-mediated signaling and function. Furthermore, we show LXR actions are differentially regulated in ...
GSEA MSigDB Browse Human Gene Sets
WebFeb 13, 2024 · Our data demonstrates cross-talks of GPI biosynthesis with glycosphingolipid biosynthesis and the ER quality control system. ... Because B3GALT4 is used in both GSL and GPI biosynthesis pathways ... WebFeb 11, 2005 · Introduction of Egghead into Mammalian Cells—Three pathways of vertebrate glycosphingolipid biosynthesis are defined by the nature of third residue added to the LacCer core (Fig. 1A).Three different enzymes are responsible for the defining steps. The neo/lacto-series contains GlcNAc in a β3 linkage to LacCer. mileage plus credit card deals
Differential Regulation of Lacto-/Neolacto- Glycosphingolipid ...
WebThe Drosophila genes, brainiac and egghead, encode glycosyltransferases predicted to act sequentially in early steps of glycosphingolipid biosynthesis, and both genes are required for development in Drosophila. egghead encodes a β4-mannosyltransferase, and brainiac encodes a β3-N-acetylglucosaminyltransferase predicted by in vitro analysis to control … Webpathways and to an understanding of the pathogenic mechanisms of a number of genetic diseases that are caused by defects in GSL-catabolizing enzymes [8]. Manipulation of GSL synthesis in animal models has led to the concept that, although cells can survive, grow and divide in the complete absence of GSLs [9], metazoa WebThis chapter describes the characteristic features of GSLs, pathways for their biosynthesis, and insights into their biological roles in membrane structure, host–pathogen interactions, cell–cell recognition, and modulation of membrane … mileageplus go card review