Chloral hydrate is dangerous mainly because
Web* Repeated exposure to Chloral may affect the liver and kidneys. IDENTIFICATION Chloral is a colorless, oily liquid with a sharp odor. It is used to make Chloral Hydrate and various pesticides. REASON FOR CITATION * Chloral is on the Hazardous Substance List because it is cited by DOT, IARC and EPA. * Definitions are provided on page 5. WebApr 3, 2024 · Chloral hydrate is metabolized into trichloroethanol, which binds to GABA receptors, resulting in CNS depression. (Gussow 2014) …
Chloral hydrate is dangerous mainly because
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WebTwo cases of chloral hydrate overdosage were associated with multiform ventricular tachycardia. Both were refractory to a number of antiarrhythmics, but responded to propranolol administration. Two of nine other cases reported in the literature also responded to beta-blocking agents. Mechanisms for the arrhythmia and its apparent response to … WebAug 21, 2024 · Chloral hydrate is a controlled substance 21 CFR 1308.14. The legal status of chloral hydrate with the United Nations and Europe, except the UK and Germany has no notations. Basically, chloral hydrate is considered a dangerous chemical, and that is about it. The UN classifies the danger of the drug as 6.1.
WebChloral hydrate is a dangerous hypnotic drug to prescribe. Lethal dose can be a small as 4 gm. Nowadays the effects on the circulatory system are most dangerous. Which … WebChloral hydrate is irritating to the GI tract, resulting in nausea, vomiting, and hemorrhagic gastritis. It may also rarely cause gastric and intestinal necrosis, which could lead to …
WebChloral hydrate, a sedative, is used in the short-term treatment of insomnia (to help you fall asleep and stay asleep for a proper rest) and to relieve anxiety and induce sleep before … WebThe use of hydrate chloral is contra-indicated in cases of gastric ulcers, hepatic insufficiency, porphyry, respiratory insufficiency, association with anticoagulants and …
Webarrhythmias secondary to chloral hydrate overdose. Of the 5 patients treated with lidocaine, only 1 had successful outcome. 26 Beta blockers are now regarded as a specific treatment for chloral hydrate-induced cardiac arrhythmias and the use of beta-blockers for refractory arrhythmias due to chloral hydrate overdoses has been reported in the ...
WebAfter chloral hydrate ingestion the partial pressure of arterial oxygen was found to be lowest at 120 minutes in the asthmatic patients and at 60 minutes in the nonasthmatic subjects. ... This finding might imply that a second dose of chloral hydrate could be dangerous for the latter group of patients. ... S. aureus is mainly involved in bovine ... the developing child bee and boyd pdfWebChloral hydrate is a geminal diol with the formula C 2 H 3 Cl 3 O 2. It is a colorless solid. ... Because of its status as a regulated substance, chloral hydrate can be difficult to obtain. This has led to chloral hydrate being replaced by … the developing child chapter 4 study guideWebChloral hydrate is dangerous mainly because. The margin b/w an effective dose and lethal dose is slight. The effectiveness of barbiturates as a sleep agent is due to the … the developing childWebchloral hydrate less than an ideal sedative. 1-4 There are a large number of studies examining the utility of chloral hydrate for procedural sedation. In the past decade, most have focused on unique patient populations or have used chloral hydrate as a standard for comparison to other sedatives. 5-8 One of the largest studies was the developing brainChloral hydrate was routinely administered in gram quantities. Prolonged exposure to the vapors is unhealthy, however, with a LD50 for 4-hour exposure of 440 mg/m . Long-term use of chloral hydrate is associated with a rapid development of tolerance to its effects and possible addiction as well as adverse effects including rashes, gastric discomfort and severe kidney, heart, and liver failure. the developing child bookWebJun 3, 2024 · Medical Definition of Chloral hydrate. Chloral hydrate: A prescription sedative/hypnotic drug developed in the 19th century. The drug acts rapidly and induces … the developing child eydfWebA commonly used oral dose of chloral hydrate is 50 mg/kg (or about 22.5 mg/lb) of body weight, with a suggested range of 40 to 60 mg/kg. 23,129–131 In a 1992 survey of pediatric residency programs, it was determined that chloral hydrate in doses between 25 and 100 mg/kg was the most common drug used for sedation. 132 the developing child textbook pdf