WebMar 1, 2024 · The total body clearance of bivalirudin in PTCA patients with normal renal function is 3.4 mL/min/kg. Metabolism. ... Total body clearance was similar for PTCA … WebTraductions en contexte de "fonction rénale ou hépatique est altérée" en français-anglais avec Reverso Context : Étant donné que la clairance du sildénafil est réduite chez les personnes âgées (65 ans et plus) et chez les patients dont la fonction rénale ou hépatique est altérée, il est préférable d'amorcer le traitement à une dose de 25 mg.
Bivalirudin Dosing Requirements in Adult Patients on
Webbivalirudin on liver and kidney function in patients subjected to these procedures. This study compared the effects of bi-valirudin and UFH on liver/renal function in patients with coronary artery disease who underwent CAG, with or with-out PCI. Methods: The study comprised 134 consecutive patients (40–89 years-old), who underwent CAG (or CAG WebBivalirudin is a 20 amino-acids hirudin-analogue with a molecular mass of 2’180 Da and a half-life of ~25 minutes; it is eliminated by proteolysis and for ~20% by renal clearance . Both bind human thrombin reversibly, … skechers san francisco store
Bivalirudin Dosing Requirements in Adult Patients on ... - LWW
WebBivalirudin is administered via continuous intravenous infusion, is removed by a combination of proteolytic cleavage by thrombin and renal clearance mechanisms, and can inhibit both soluble and clot-bound thrombin. ... Bivalirudin concentration may be affected by drug interactions, liver, and renal disease. WebThe hepatic clearance is more complex than renal clearance. Like renal clearance, hepatic clearance involves filtering of the blood. Small-molecule drugs, viruses, bacteria or nanoparticles in the blood can be taken up by sinusoidal endothelial cells, hepatocytes, and Kupffer cells in the liver (Zhang et al., 2016). Kupffer cells and ... WebJul 25, 2024 · The average duration of heparin therapy prior to starting bivalirudin was 8 days (range: 1-26 days), with bivalirudin being utilized for a median of 9.5 days and … skechers scarpe memory foam